How subunit coupling produces the -subunit rotary motion in F1-ATPase
نویسندگان
چکیده
منابع مشابه
How subunit coupling produces the -subunit rotary motion in F1-ATPase
FoF1-ATP synthase manufactures the energy ‘‘currency,’’ ATP, of living cells. The soluble F1 portion, called F1-ATPase, can act as a rotary motor, with ATP binding, hydrolysis, and product release, inducing a torque on the -subunit. A coarse-grained plastic network model is used to show at a residue level of detail how the conformational changes of the catalytic -subunits act on the -subunit th...
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Unraveling the molecular nature of the conversion of chemical energy (ATP hydrolysis in the α/β-subunits) to mechanical energy and torque (rotation of the γ-subunit) in F1-ATPase is very challenging. A major part of the challenge involves understanding the rotary-chemical coupling by a nonphenomenological structure-energy description, while accounting for the observed torque generated on the γ-...
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The subunit of bacterial and chloroplast FoF1-ATP synthases modulates their ATP hydrolysis activity. Here, we report the crystal structure of the ATP-bound subunit from a thermophilic Bacillus PS3 at 1.9-Å resolution. The C-terminal two -helices were folded into a hairpin, sitting on the sandwich structure, as reported for Escherichia coli. A previously undescribed ATP binding motif, I(L)DXXRA,...
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MgADP inhibition, which is considered as a part of the regulatory system of ATP synthase, is a well-known process common to all F1-ATPases, a soluble component of ATP synthase. The entrapment of inhibitory MgADP at catalytic sites terminates catalysis. Regulation by the ε subunit is a common mechanism among F1-ATPases from bacteria and plants. The relationship between these two forms of regulat...
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The NH2 terminus of the yeast F1-ATPase beta subunit precursor directs the import of this protein into mitochondria. To define the functionally important components of this import signal, oligonucleotide-directed mutagenesis was used to introduce a series of deletion and missense mutations into the gene encoding the F1-beta subunit precursor. Among these mutations were three nonoverlapping dele...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0708746105